Pub. Date : 2021 Mar 11
PMID : 33799790
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Tioconazole and Chloroquine Act Synergistically to Combat Doxorubicin-Induced Toxicity via Inactivation of PI3K/AKT/mTOR Signaling Mediated ROS-Dependent Apoptosis and Autophagic Flux Inhibition in MCF-7 Breast Cancer Cells. | Doxorubicin | mechanistic target of rapamycin kinase | Homo sapiens |
2 | These results suggest CQ and/or TIC combination with DOX could act as effective cocktail therapy targeting autophagy and PI3K/AKT/mTOR pathways in MCF-7 breast cancer cells and hence, sensitizes cancer cells to doxorubicin treatment and combat its toxicity. | Doxorubicin | mechanistic target of rapamycin kinase | Homo sapiens |