Pub. Date : 2021 Jul 1
PMID : 33798579
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Antioxidant activity of calycosin against alpha-synuclein amyloid fibrils-induced oxidative stress in neural-like cells as a model of preventive care studies in Parkinson"s disease. | 7,3'-dihydroxy-4'-methoxyisoflavone | synuclein alpha | Homo sapiens |
| 2 | In the present study, the anti-fibrillation activity of calycosin and its influence on the kinetics of amyloid formation of alpha-synuclein (alpha-syn) and associated cytotoxicity on neuron-like cells (PC-12) as a model of Parkinson"s disease were explored. | 7,3'-dihydroxy-4'-methoxyisoflavone | synuclein alpha | Homo sapiens |
| 3 | In the present study, the anti-fibrillation activity of calycosin and its influence on the kinetics of amyloid formation of alpha-synuclein (alpha-syn) and associated cytotoxicity on neuron-like cells (PC-12) as a model of Parkinson"s disease were explored. | 7,3'-dihydroxy-4'-methoxyisoflavone | synuclein alpha | Homo sapiens |
| 4 | The experimental analysis indicated that calycosin exert its antioxidant effects against alpha-syn amyloid-triggered neurotoxicity by modifying the aggregation pathway toward formation of nontoxic spices via recovering the activity of SOD/CAT and GSH content and reducing the ROS content and caspase-3 activity. | 7,3'-dihydroxy-4'-methoxyisoflavone | synuclein alpha | Homo sapiens |
| 5 | This work may provide useful information about the mechanism of alpha-syn amyloid inhibition by calycosin and pave the way for developing some small molecules-based therapeutic platforms against Parkinson"s diseases. | 7,3'-dihydroxy-4'-methoxyisoflavone | synuclein alpha | Homo sapiens |