Title : Changes in expression of TLR-4, TGF-β, INF-γ, TNF-α in cultured T24/83 cells of invasive bladder cancer treated with cisplatin and/or polyphenolic adjuvant melanin.

Pub. Date : 2021 Mar

PMID : 33785718






2 Functional Relationships(s)
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1 The combined use of cisplatin and melanin decreased TGF-beta expression by 6.5 times. Melanins transforming growth factor alpha Homo sapiens
2 CONCLUSIONS: Melanin, cisplatin, and combination of both agents affect significantly TLR4, TNF-alpha, TGF-beta, INF-gamma expression, cell cycle distribution and morphology in T24/83 cells suggesting their transition to less aggressive phenotype. Melanins transforming growth factor alpha Homo sapiens