Title : The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation.

Pub. Date : 2021 Mar 29

PMID : 33782411






2 Functional Relationships(s)
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1 Meanwhile, MTHFD2 drives the folate cycle to sustain sufficient uridine-related metabolites including UDP-GlcNAc, which promotes the global O-GlcNAcylation of proteins including cMYC, resulting in increased cMYC stability and PD-L1 transcription. Folic Acid MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 Meanwhile, MTHFD2 drives the folate cycle to sustain sufficient uridine-related metabolites including UDP-GlcNAc, which promotes the global O-GlcNAcylation of proteins including cMYC, resulting in increased cMYC stability and PD-L1 transcription. Folic Acid MYC proto-oncogene, bHLH transcription factor Homo sapiens