Title : Localization of the binding site on fibrin for the secondary binding site of thrombin.

Pub. Date : 1988 Mar 22

PMID : 3378041






2 Functional Relationships(s)
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1 Chromatography of various domains of the central nodule (desAB-NDSK, fibrinogen E, and fibrin E) having nonidentical amino acid sequences showed that all of these fragments are capable of binding to PMSF-thrombin-Sepharose, suggesting that the thrombin binding site resides within the peptide regions common to all of these fragments: alpha(Gly17-Met51), beta(Val55-Met118), and gamma(Tyr1-Lys53). Sepharose coagulation factor II, thrombin Homo sapiens
2 Chromatography of the isolated chains of fibrinogen E showed that the alpha(Gly17-Lys78) peptide region itself contains a strong binding site for PMSF-thrombin-Sepharose. Sepharose coagulation factor II, thrombin Homo sapiens