Title : Evaluation of pteroyl-S-alkylhomocysteine sulfoximines as inhibitors of mammalian folylpolyglutamate synthetase.

Pub. Date : 1988 May 15

PMID : 3377808






1 Functional Relationships(s)
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1 These results, taken together with previously established structure-activity correlations, imply that a negative charge at the gamma-position of folate analogs may be required for initial binding to FPGS and thus constitutes a prerequisite for activity of potential mechanism-based inhibitors of this enzyme. Folic Acid folylpolyglutamyl synthetase Mus musculus