PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3377808-5 1988 These results, taken together with previously established structure-activity correlations, imply that a negative charge at the gamma-position of folate analogs may be required for initial binding to FPGS and thus constitutes a prerequisite for activity of potential mechanism-based inhibitors of this enzyme. Folic Acid 145-151 folylpolyglutamyl synthetase Mus musculus 199-203