Title : Inhibition of CCl4 metabolism by oxygen varies between isoenzymes of cytochrome P-450.

Pub. Date : 1988 May 16

PMID : 3377780






2 Functional Relationships(s)
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1 Oxygen inhibition of CCl4 metabolism by different isoenzymes of cytochrome P-450 was assessed by studying liver microsomes isolated from control rats and rats treated with phenobarbital or isoniazid. Isoniazid C-C motif chemokine ligand 4 Rattus norvegicus
2 Rats treated with phenobarbital, which increases hepatic cytochrome P-450 content, or isoniazid, which does not increase hepatic cytochrome P-450 content, both metabolized more CCl4 than control rats as indicated by exhalation of greater quantities of CCl4 metabolites and by an increase in CCl4 toxicity. Isoniazid C-C motif chemokine ligand 4 Rattus norvegicus