Title : Hydrogen enriched saline alleviates morphine tolerance via inhibiting neuroinflammation, GLT-1, GS nitration and NMDA receptor trafficking and functioning in the spinal cord of rats.

Pub. Date : 2021 Jun 11

PMID : 33774150






1 Functional Relationships(s)
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1 Chronic morphine administration induced antinociceptive tolerance, and together led to increased TNF-alpha, IL-1beta and IL-6 expression, astrocyte activation, GLT-1 and GS nitration, increased membrane and total NR1, NR2B expression. Morphine tumor necrosis factor Rattus norvegicus