Title : Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway.

Pub. Date : 2021 Mar 23

PMID : 33758188






1 Functional Relationships(s)
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1 Treatment with an mTOR inhibitor rapamycin ameliorates aberrant expansion of the HSC compartment as well as dysregulated hematopoiesis in aged ASXL1-MT KI mice. Sirolimus mechanistic target of rapamycin kinase Mus musculus