Pub. Date : 2021 Jun
PMID : 33755912
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Indole-3-carboxaldehyde regulates RSV-induced inflammatory response in RAW264.7 cells by moderate inhibition of the TLR7 signaling pathway. | indole-3-carbaldehyde | toll-like receptor 7 | Mus musculus |
| 2 | Furthermore, we revealed that indole-3-carboxaldehyde suppressed transcription of IFN-alpha by inhibiting RSV-induced TLR7 expression in RAW264.7 cells. | indole-3-carbaldehyde | toll-like receptor 7 | Mus musculus |
| 3 | Additionally, indole-3-carboxaldehyde inhibited RSV-induced NF-kappaB signalling activation in a TLR7-MyD88-dependent manner. | indole-3-carbaldehyde | toll-like receptor 7 | Mus musculus |
| 4 | Together, our findings suggest that indole-3-carboxaldehyde inhibited RSV-induced inflammatory injury by moderate regulation of TLR7 signaling pathway and did not significantly affect the viral clearance competence of the innate immune system. | indole-3-carbaldehyde | toll-like receptor 7 | Mus musculus |