Pub. Date : 2021
PMID : 33754076
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Results: The PPARgamma agonists rosiglitazone and pioglitazone blocked glutaminolysis but not glycolysis under Th17-skewing conditions, as indicated by the detection of intracellular lactate and alpha-KG and the fluorescence ratios of BCECF-AM. | Rosiglitazone | peroxisome proliferator activated receptor gamma | Mus musculus |
| 2 | However, the limitation of PPARgamma agonists on the mRNA expression of RORgammat was unable to be stopped by 2-HG but was attributed to GSH/ROS signals subsequent to GLS1. | Rosiglitazone | peroxisome proliferator activated receptor gamma | Mus musculus |
| 3 | Conclusion: PPARgamma agonists repressed Th17 responses by counteracting GLS1-mediated glutaminolysis/2-HG/H3K4me3 and GSH/ROS signals, which is beneficial for Th17 cell-related immune dysregulation. | Rosiglitazone | peroxisome proliferator activated receptor gamma | Mus musculus |