Pub. Date : 2021 Aug 15
PMID : 33753114
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | After co-culture of Hep3B cells and PBMCs, curcumin had a synergistic effect with anti-PD-1 to slow Hep3B cell proliferation, activate lymphocytes, inhibit immune evasion, and down-regulate TGF-beta1 expression. | Curcumin | transforming growth factor beta 1 | Homo sapiens |
| 2 | Functionally, curcumin inhibited thrombin to reduce P300-induced histone acetylation in the TGF-beta1 promoter region, and anti-PD-1 suppressed binding of PD-1 and PD-L1 to promote immune activity; the combination of the two showed better in vitro anti-cancer effects. | Curcumin | transforming growth factor beta 1 | Homo sapiens |