Title : Homocysteine induced a calcium-mediated disruption of mitochondrial function and dynamics in endothelial cells.

Pub. Date : 2021 May

PMID : 33751715






2 Functional Relationships(s)
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1 The accumulation of mitochondrial calcium could be blocked by inhibiting with the IP3R inhibitor Xestospongin C (XeC) in Hcy-treated cells. Calcium inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens
2 In conclusion, Hcy-induced mitochondrial dysfunction and dynamics disorder in endothelial cells were mainly related to the increase of calcium as a result of the upregulated expressions of the MCU and the IP3R-Grp75-VDAC complex in MAMs. Calcium inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens