Title : Orphan nuclear receptors as regulators of intratumoral androgen biosynthesis in castration-resistant prostate cancer.

Pub. Date : 2021 Apr

PMID : 33750894






1 Functional Relationships(s)
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1 Steroidogenic enzymes, such as CYP11A1, CYP17A1, HSD3B1, AKR1C3 and SRD5A, are essential to catalyze the conversion of the initial substrate cholesterol into potent androgens that confers the CRPC progression. Cholesterol cytochrome P450 family 17 subfamily A member 1 Homo sapiens