Title : The Discovery of Novel BCR-ABL Tyrosine Kinase Inhibitors Using a Pharmacophore Modeling and Virtual Screening Approach.

Pub. Date : 2021

PMID : 33748144






1 Functional Relationships(s)
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1 Although the use of the BCR-ABL tyrosine kinase inhibitors (TKIs), such as imatinib, nilotinib, dasatinib, bosutinib, and ponatinib have increased the overall survival of CML patients, their use is limited by drug resistance and severe adverse effects. Dasatinib ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens