Title : Discovery of 5-(N-hydroxycarbamimidoyl) benzofuran derivatives as novel indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.

Pub. Date : 2021 May 15

PMID : 33741464






1 Functional Relationships(s)
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1 The molecular modeling of 19 with the X-ray crystal structure of IDO1 indicated that dipole-ionic interactions with heme iron, halogen bonding with Cys129 and the two hydrophobic interactions were important for the high potency of 19. Iron indoleamine 2,3-dioxygenase 1 Homo sapiens