CPRiL

4 Functional Relationships(s) Download
	Sentence	Compound Name	Protein Name	Organism
1	Genetic polymorphisms of CYP2C9, the main enzyme involved in the metabolism of sulfonylureas, have been associated with the risk of severe hypoglycaemia, particularly in poor metabolizers carrying CYP2C9 3/3 genotype, and especially in the case of patients treated with glimepiride.	glimepiride	cytochrome P450 family 2 subfamily C member 9	Homo sapiens
2	Genetic polymorphisms of CYP2C9, the main enzyme involved in the metabolism of sulfonylureas, have been associated with the risk of severe hypoglycaemia, particularly in poor metabolizers carrying CYP2C9 3/3 genotype, and especially in the case of patients treated with glimepiride.	glimepiride	cytochrome P450 family 2 subfamily C member 9	Homo sapiens
3	The objectives of the present study were to evaluate the potential clinical and economic outcomes of using CYP2C9 genotype data to guide the management of SU regimen in patients initiating glimepiride therapy, and to identify factors affecting the cost-effectiveness of this treatment scheme.	glimepiride	cytochrome P450 family 2 subfamily C member 9	Homo sapiens
4	In conclusion, the potential cost of CYP2C9 genotype-guided dosing for glimepiride therapy is relatively high, and associated with modest improvements with respect to the number of hypoglycaemia avoided, as compared with standard dosing.	glimepiride	cytochrome P450 family 2 subfamily C member 9	Homo sapiens