Title : α1A-adrenaline receptors in dorsal horn inhibitory neurons have an inhibitory role in the regulation of chloroquine-induced itch in mice.

Pub. Date : 2021 Mar 16

PMID : 33726812






1 Functional Relationships(s)
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1 Mice with conditional knock-out of alpha1A-ARs in inhibitory interneurons (Vgat-Cre;Adra1aflox/flox mice) exhibited an increase in scratching behavior when induced by an intradermal injection of chloroquine, but not compound 48/80, which are known as models of histamine-independent and dependent itch, respectively. Histamine adrenergic receptor, alpha 1d Mus musculus