Title : PPARG in osteocytes controls sclerostin expression, bone mass, marrow adiposity and mediates TZD-induced bone loss.

Pub. Date : 2021 Jun

PMID : 33722775






1 Functional Relationships(s)
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Protein Name
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1 The 8 kb sequence upstream of Sost gene transcription start site possesses multiple PPARG binding elements (PPREs) with at least two of them binding PPARG with dynamics reflecting its activation with full agonist rosiglitazone and correlating with increased levels of Sost transcript and sclerostin protein expression (Pearson"s r = 0.9910, p = 0.001). Rosiglitazone sclerostin Mus musculus