| Protein Name | sclerostin |
|---|---|
| Organism | Mus musculus |
| Gene ID | 74499 |
| Gene Symbol | Sost |
| UniProt | Q99P68 (SOST_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
61
Total Number of Articles : 65 |
Description |
sclerostin |
| Gene Summary |
Predicted to enable several functions, including BMP binding activity; DNA-binding transcription factor binding activity; and carbohydrate binding activity. Acts upstream of or within negative regulation of ossification; negative regulation of signal transduction; and ossification. Predicted to be located in Golgi apparatus. Predicted to be part of protein-containing complex. Predicted to be active in extracellular space. Is expressed in several structures, including arterial system; jaw; limb bud; nervous system; and skeleton. Used to study SOST-related sclerosing bone dysplasia and sclerosteosis 1. Human ortholog(s) of this gene implicated in autosomal dominant craniodiaphyseal dysplasia; sclerosteosis; and sclerosteosis 1. Orthologous to human SOST (sclerostin). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |