Title : Short-term perfluorooctane sulfonate exposure impairs Leydig cell regeneration in the adult rat testis via targeting hedgehog signaling.

Pub. Date : 2021 May

PMID : 33721578






1 Functional Relationships(s)
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1 Perfluorooctane sulfonate significantly lowered serum testosterone levels, reduced the number of regenerated Leydig cells, down-regulated the expression of Lhcgr, Scarb1, Star, Cyp11a1, Hsd3b1, Cyp17a1, and Dhh) and their proteins at doses of 5 and 10 mg/kg 35 and 56 days after ethane dimethane sulfonate. perfluorooctane sulfonic acid cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus