Title : Identification of viable TCDD access pathways to human AhR PAS-B ligand binding domain.

Pub. Date : 2021 Jun

PMID : 33706219






6 Functional Relationships(s)
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1 Identification of viable TCDD access pathways to human AhR PAS-B ligand binding domain. Polychlorinated Dibenzodioxins aryl hydrocarbon receptor Homo sapiens
2 The main mechanism of action of TCDD in humans involves binding to the Aryl hydrocarbon Receptor (AhR). Polychlorinated Dibenzodioxins aryl hydrocarbon receptor Homo sapiens
3 The main mechanism of action of TCDD in humans involves binding to the Aryl hydrocarbon Receptor (AhR). Polychlorinated Dibenzodioxins aryl hydrocarbon receptor Homo sapiens
4 Although qualitatively established, TCDD capture by the AhR remains poorly characterized at the molecular level. Polychlorinated Dibenzodioxins aryl hydrocarbon receptor Homo sapiens
5 Starting from a recently developed structural model of the human AhR PAS-B domain, in this work we attempt the identification of viable TCDD access pathways to the human AhR ligand binding domain by means of molecular dynamics. Polychlorinated Dibenzodioxins aryl hydrocarbon receptor Homo sapiens
6 Starting from a recently developed structural model of the human AhR PAS-B domain, in this work we attempt the identification of viable TCDD access pathways to the human AhR ligand binding domain by means of molecular dynamics. Polychlorinated Dibenzodioxins aryl hydrocarbon receptor Homo sapiens