Title : Blockade of SARS-CoV-2 infection in vitro by highly potent PI3K-α/mTOR/BRD4 inhibitor.

Pub. Date : 2021 Mar 5

PMID : 33688653






1 Functional Relationships(s)
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1 One Sentence Summary: Evidence of in silico designed chemotype (SF2523) targeting PI3K-alpha/mTOR/BRD4 inhibits SARS-CoV-2 infection and is highly synergistic with remdesivir. remdesivir phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Homo sapiens