Title : SMAD4 loss limits the vulnerability of pancreatic cancer cells to complex I inhibition via promotion of mitophagy.

Pub. Date : 2021 Apr

PMID : 33686239






1 Functional Relationships(s)
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1 Interestingly, mitochondria-targeted tamoxifen, a complex I inhibitor under clinical trial, overcomes resistance mediated by SMAD4-deficiency or TGFbeta signaling. Tamoxifen transforming growth factor alpha Homo sapiens