Title : Induction of macrophage pyroptosis-related factors by pathogenic E. coli high pathogenicity island (HPI) in Yunnan Saba pigs.

Pub. Date : 2021 Mar 7

PMID : 33678162






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1 CONCLUSION: Our findings indicate that pathogenic E. coli HPI infection of Saba pigs causes pyroptosis of macrophages characterized by upregulated expression of pyroptosis key factors in the NLRP3/ASC/caspase-1 signaling pathway, direct cell membrane pore formation, and secretion of the inflammatory factor IL-1beta and IL-18 downstream of NLRP3 and caspase-1 activation to enhance the inflammatory response. 3-(2-(4-azidobenzamidino)ethyl)-5-hydroxyindole interleukin 1 alpha Sus scrofa