Title : NUPR1- CHOP experssion, autophagosome formation and apoptosis in the postmortem striatum of chronic methamphetamine user.

Pub. Date : 2021 Jul

PMID : 33675952






3 Functional Relationships(s)
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1 The current study aimed to assess the specific relationship between long-term Meth exposure and several endoplasmic reticulum stress-,autophagy-,and apoptosis-associated markers including C/EBP homologous protein (CHOP), Tribbles homolog 3(Trib3), Nuclear protein 1(NUPR1), and Beclin-1 expression in postmortem human striatum. Methamphetamine beclin 1 Homo sapiens
2 Based on our findings, the expression level of CHOP, Trib3, NUPR1, and Beclin-1 in the striatum of Meth group were significantly higher comparing the control group. Methamphetamine beclin 1 Homo sapiens
3 Beclin 1 expression was also upregulated which may due to the activation of autophagic mechanisms upon prolonged Meth exposure. Methamphetamine beclin 1 Homo sapiens