Pub. Date : 2021 Feb 12
PMID : 33673103
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study evaluated the effect of anandamide (AEA) on interleukin (IL)-1beta synthesis and gene expression of IL-1beta, its type I (IL-1R1) and II (IL-1R2) receptors, and IL-1 receptor antagonist (IL-1RN) in the hypothalamic structures, involved in the central control of reproduction, during inflammation. | aea | interleukin 1 alpha | Homo sapiens |
| 2 | AEA injection (p < 0.05) suppressed LPS-induced expression of IL-1beta protein in the hypothalamus. | aea | interleukin 1 alpha | Homo sapiens |
| 3 | The gene expression of IL-1beta, IL-1RN, and IL-1R2 in the hypothalamic structures was higher (p < 0.05) in animals treated with both LPS and AEA in comparison to other experimental groups. | aea | interleukin 1 alpha | Homo sapiens |
| 4 | Our study shows that AEA suppressed IL-1beta synthesis in the hypothalamus, likely affecting posttranscriptional levels of this cytokine synthesis. | aea | interleukin 1 alpha | Homo sapiens |