Title : Development of a protein signature to enable clinical positioning of IAP inhibitors in colorectal cancer.

Pub. Date : 2021 Sep

PMID : 33660894






1 Functional Relationships(s)
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1 We quantified the absolute expression of 19 key apoptotic proteins at baseline in a panel of 12 CRC cell lines representative of the genetic diversity seen in this disease to identify which proteins promote resistance or sensitivity to a model IAP antagonist (Birinapant) alone and in combination with SoC chemotherapy (5-FU plus Oxaliplatin). birinapant alkaline phosphatase, intestinal Homo sapiens