Title : Substrate-Specific Allosteric Effects on the Enhancement of CYP17A1 Lyase Efficiency by Cytochrome b5.

Pub. Date : 2021 Mar 17

PMID : 33656879






1 Functional Relationships(s)
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1 For CYP17A1 with 17OH-PROG, a characteristic shift of the Fe-O mode is observed in the presence of Mn-b5, indicating reorientation of a hydrogen bond between the 17OH group of the substrate from the terminal to the proximal oxygen atom of the Fe-O-O moiety, a configuration favorable for the lyase catalysis. prog cytochrome P450 family 17 subfamily A member 1 Homo sapiens