Title : Identification of human cytochrome P450 isozymes involved in the oxidative metabolism of carfentanil.

Pub. Date : 2021 Jun 1

PMID : 33652071






1 Functional Relationships(s)
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1 These findings indicate that CYP3A5, CYP3A4, CYP2C8 and CYP2C9 play a major role in the transformation of carfentanil to M1 (norcarfentanil), M11, M13 and M15 through N-dealkylation of piperidine ring, hydroxylation of phenethyl group and ketone formation on phenethyl linker by human liver micrsomes. Norcarfentanil cytochrome P450 family 2 subfamily C member 9 Homo sapiens