Pub. Date : 2021 Jun
PMID : 33646450
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PPAR-delta activation reduces cisplatin-induced apoptosis via inhibiting p53/Bax/caspase-3 pathway without modulating autophagy in murine renal proximal tubular cells. | Cisplatin | peroxisome proliferator activator receptor delta | Mus musculus |
| 2 | Thus, PPAR-delta may protect against cisplatin-induced kidney injury. | Cisplatin | peroxisome proliferator activator receptor delta | Mus musculus |
| 3 | METHODS: We examined the protective effects of PPAR-delta activation on cisplatin-induced cellular injury and their detailed mechanisms in a murine renal proximal tubular (mProx) cell line using GW0742, an authentic PPAR-delta activator. | Cisplatin | peroxisome proliferator activator receptor delta | Mus musculus |
| 4 | The inhibitory effect of GW0742 on cisplatin-induced caspase-3 activation was significantly diminished by silencing of the PPAR-delta gene expression. | Cisplatin | peroxisome proliferator activator receptor delta | Mus musculus |