Pub. Date : 2021
PMID : 33644040
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MiR-132-3p Modulates MEKK3-Dependent NF-kappaB and p38/JNK Signaling Pathways to Alleviate Spinal Cord Ischemia-Reperfusion Injury by Hindering M1 Polarization of Macrophages. | mir-132-3p | mitogen activated protein kinase 14 | Rattus norvegicus |
| 2 | miR-132-3p could directly bind to MEKK3, and that macrophage M1 polarization and inflammation could be inhibited by overexpression of miR-132-3p through downregulating MEKK3 and inactivating the NF-kappaB and p38/JNK signaling pathways. | mir-132-3p | mitogen activated protein kinase 14 | Rattus norvegicus |
| 3 | miR-132-3p could directly bind to MEKK3, and that macrophage M1 polarization and inflammation could be inhibited by overexpression of miR-132-3p through downregulating MEKK3 and inactivating the NF-kappaB and p38/JNK signaling pathways. | mir-132-3p | mitogen activated protein kinase 14 | Rattus norvegicus |
| 4 | Overall, our study demonstrated that miR-132-3p can suppress M1 polarization of macrophages and alleviate SCIR injury by blocking the MEKK3-dependent activation of the NF-kappaB and p38/JNK signaling pathway. | mir-132-3p | mitogen activated protein kinase 14 | Rattus norvegicus |