Title : OTUB1 stabilizes mismatch repair protein MSH2 by blocking ubiquitination.

Pub. Date : 2021 Jan-Jun

PMID : 33640455






1 Functional Relationships(s)
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Protein Name
Organism
1 Depleting OTUB1 in cells promotes the ubiquitination and subsequent degradation of MSH2, leading to greater mutation frequency and cellular resistance to genotoxic agents, including the common chemotherapy agents N-methyl-N"-nitro-N-nitrosoguanidine and cisplatin. Cisplatin mutS homolog 2 Homo sapiens