Title : Analyzing the driving forces of insulin stability in the basic amino acid solutions: A perspective from hydration dynamics.

Pub. Date : 2021 Feb 28

PMID : 33639734






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Insulin, when tested with these solutions, was found to show rigid conformations, relative to that in pure water. Water insulin Homo sapiens
2 Our study reveals that the loss of configurational entropy of insulin in arginine solution, as compared to that in pure water, is more as compared to the entropy loss in the other two amino acid solutions, which, moreover, was found to be due to the presence of motionally bound less entropic hydration water of insulin in arginine solution than in histidine or lysine solution. Water insulin Homo sapiens
3 Our study reveals that the loss of configurational entropy of insulin in arginine solution, as compared to that in pure water, is more as compared to the entropy loss in the other two amino acid solutions, which, moreover, was found to be due to the presence of motionally bound less entropic hydration water of insulin in arginine solution than in histidine or lysine solution. Water insulin Homo sapiens