Title : High Dosages of Equine Chorionic Gonadotropin Exert Adverse Effects on the Developmental Competence of IVF-Derived Mouse Embryos and Cause Oxidative Stress-Induced Aneuploidy.

Pub. Date : 2020

PMID : 33634101






1 Functional Relationships(s)
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1 Additionally, the appearance of gammaH2AX and the significantly increased expression of Aurora B and MAD2L1 suggested that administration of relatively high doses of eCG caused Aurora B-mediated SAC activation triggered by ROS-induced DNA damage in early mouse IVF-derived embryos for self-correction of aneuploidy formation. Reactive Oxygen Species MAD2 mitotic arrest deficient-like 1 Mus musculus