Title : Identification BCL6 and miR-30 family associating with Ibrutinib resistance in activated B-cell-like diffuse large B-cell lymphoma.

Pub. Date : 2021 Feb 25

PMID : 33629212






4 Functional Relationships(s)
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1 Identification BCL6 and miR-30 family associating with Ibrutinib resistance in activated B-cell-like diffuse large B-cell lymphoma. ibrutinib BCL6 transcription repressor Homo sapiens
2 In addition, another expression profile from GEO database showed that BCL6 was significantly high expression in no responsive patients after Ibrutinib treatment, and the receiver operating characteristic (ROC) curve which was used to evaluate the relationship between BCL6 expression and its effect was 0.67. ibrutinib BCL6 transcription repressor Homo sapiens
3 MTT assay showed that treatment with FX1 (a BCL6 inhibitor) can enhance the sensitivity of Ibrutinib in C481S BTK HBL-1 cells. ibrutinib BCL6 transcription repressor Homo sapiens
4 The results suggested that BCL6 and miR-30 family maybe associate with Ibrutinib resistance in ABC-DLBCL. ibrutinib BCL6 transcription repressor Homo sapiens