| Protein Name | BCL6 transcription repressor |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 604 |
| Gene Symbol | BCL6 |
| UniProt | P41182 (BCL6_HUMAN), B5B0A5 (B5B0A5_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
168
Total Number of Articles : 185 |
Description |
BCL6 transcription repressor |
| Gene Summary |
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015] |
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