Protein Name BCL6 transcription repressor
Organism Homo sapiens
Gene ID 604
Gene Symbol


UniProt P41182 (BCL6_HUMAN), B5B0A5 (B5B0A5_HUMAN)
Relationships Total Number of functionally related compound(s) : 168
Total Number of Articles : 185

BCL6 transcription repressor

Gene Summary

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

  • B-cell lymphoma 6 protein
  • B cell CLL/lymphoma 6
  • B-cell lymphoma 5 protein
Click to show/hide the synonyms