Title : Redox-active phytoconstituents ameliorate cell damage and inflammation in rat hippocampal neurons exposed to hyperglycemia+Aβ1-42 peptide.

Pub. Date : 2021 May

PMID : 33610590






1 Functional Relationships(s)
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1 The GLU + Abeta1-42 treatment significantly decreased cell viability, increased ROS formation, reduced superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activities, augmented Advanced Glycation End Products- and 4-hydroxynonenal-adducts generation, increased 3-nitrotyrosine and inflammatory outcomes such as inducible nitric oxide synthase, interleukin 1beta and Tumor Necrosis Factor alpha, decreased MMP and augmented amyloid aggregation. Glucose nitric oxide synthase 2 Rattus norvegicus