Pub. Date : 2021 Apr 16
PMID : 33610557
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we test the effects of Brazilin on both seeded and unseeded alpha-syn fibril formation and show that the natural polyphenol inhibits fibrillogenesis of alpha-syn by a unique mechanism that alters conformational equilibria in two separate points of the assembly mechanism: Brazilin preserves the natively unfolded state of alpha-syn by specifically binding to the compact conformation of the alpha-syn monomer. | Polyphenols | synuclein alpha | Homo sapiens |
| 2 | Here we test the effects of Brazilin on both seeded and unseeded alpha-syn fibril formation and show that the natural polyphenol inhibits fibrillogenesis of alpha-syn by a unique mechanism that alters conformational equilibria in two separate points of the assembly mechanism: Brazilin preserves the natively unfolded state of alpha-syn by specifically binding to the compact conformation of the alpha-syn monomer. | Polyphenols | synuclein alpha | Homo sapiens |
| 3 | Here we test the effects of Brazilin on both seeded and unseeded alpha-syn fibril formation and show that the natural polyphenol inhibits fibrillogenesis of alpha-syn by a unique mechanism that alters conformational equilibria in two separate points of the assembly mechanism: Brazilin preserves the natively unfolded state of alpha-syn by specifically binding to the compact conformation of the alpha-syn monomer. | Polyphenols | synuclein alpha | Homo sapiens |