Title : Assessment of drug transporters involved in the urinary secretion of [99mTc]dimercaptosuccinic acid.

Pub. Date : 2021 Mar-Apr

PMID : 33609918






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 [99mTc]DMSA uptake into vesicles that highly expressed MRP2 was significantly higher in adenosine triphosphate (ATP) than in adenosine monophosphate (AMP), and probenecid decreased uptake to similar levels as that in AMP. Succimer ATP binding cassette subfamily C member 2 Homo sapiens
2 CONCLUSIONS: [99mTc]DMSA accumulates in renal proximal tubular epithelial cells from blood via OAT3 on the basolateral side, and then a small volume of [99mTc]DMSA will be excreted in urine via MRP2. Succimer ATP binding cassette subfamily C member 2 Homo sapiens
3 ADVANCES IN KNOWLEDGE: [99mTc]DMSA accumulates via OAT3 in renal proximal tubular epithelial cells and is slightly excreted from the cells via MRP2. Succimer ATP binding cassette subfamily C member 2 Homo sapiens