Pub. Date : 2021 Apr
PMID : 33593942
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | CF10 is a 2nd generation polymeric fluoropyrimidine (FP) that targets both thymidylate synthase (TS), the target of 5-fluorouracil (5-FU), and DNA topoisomerase 1 (Top1), the target of irinotecan, two drugs that are key components of FOLFIRNOX, a standard of care regimen for pancreatic ductal adenocarcinoma (PDAC). | 2-fluoropyrimidine | DNA topoisomerase I | Homo sapiens |
2 | CF10 is a 2nd generation polymeric fluoropyrimidine (FP) that targets both thymidylate synthase (TS), the target of 5-fluorouracil (5-FU), and DNA topoisomerase 1 (Top1), the target of irinotecan, two drugs that are key components of FOLFIRNOX, a standard of care regimen for pancreatic ductal adenocarcinoma (PDAC). | 2-fluoropyrimidine | DNA topoisomerase I | Homo sapiens |