Pub. Date : 2021 Mar 2
PMID : 33591178
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | p53 Is Potentially Regulated by Cyclophilin D in the Triple-Proline Loop of the DNA Binding Domain. | Proline | tumor protein p53 | Homo sapiens |
| 2 | We have identified the specific cyclophilin D binding site on p53 that is located at proline 151 in the DNA binding domain. | Proline | tumor protein p53 | Homo sapiens |
| 3 | As a peptidyl-prolyl isomerase, cyclophilin D binds p53 and catalyzes the cis-trans isomerization of the peptide bond preceding proline 151. | Proline | tumor protein p53 | Homo sapiens |
| 4 | We have also characterized the effect of such an isomerization and found that the p53 domain in the cis state is overall more rigid than the trans state except for the local region around proline 151. | Proline | tumor protein p53 | Homo sapiens |