PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33591178-0 2021 p53 Is Potentially Regulated by Cyclophilin D in the Triple-Proline Loop of the DNA Binding Domain. Proline 60-67 tumor protein p53 Homo sapiens 0-3 33591178-6 2021 We have identified the specific cyclophilin D binding site on p53 that is located at proline 151 in the DNA binding domain. Proline 85-92 tumor protein p53 Homo sapiens 62-65 33591178-7 2021 As a peptidyl-prolyl isomerase, cyclophilin D binds p53 and catalyzes the cis-trans isomerization of the peptide bond preceding proline 151. Proline 128-135 tumor protein p53 Homo sapiens 52-55 33591178-8 2021 We have also characterized the effect of such an isomerization and found that the p53 domain in the cis state is overall more rigid than the trans state except for the local region around proline 151. Proline 188-195 tumor protein p53 Homo sapiens 82-85