Pub. Date : 2021 Aug 1
PMID : 33587352
14 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nuclear Her2 contributes to paclitaxel resistance in breast cancer cells. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 2 | Here, we tested whether nuclear Her2 contributes to paclitaxel resistance in Her2-overexpressing breast cancer cells. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 3 | Paclitaxel-resistant breast cancer cell was also developed and nuclear Her2 expression was tested. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 4 | Then, correlation between nuclear Her2 and resistance to paclitaxel were analyzed. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 5 | RESULTS: We found that Her2 overexpression increases Her2 nuclear expression and cells resistance to paclitaxel in MCF-7 cells. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 6 | In the paclitaxel resistant cell (SK-BR-3/R), nuclear Her2 expression is upregulated compared with parental SK-BR-3 cells. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 7 | Increased expression of nuclear Her2 after short-time (48 h) treatment of paclitaxel was also observed in SK-BR-3 cells. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 8 | Further downregulation of Her2 nuclear expression through blocking expression of importin beta1 sensitizes the cells to paclitaxel. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 9 | The analysis showed that the Her2 nuclear expression increases the survivin expression which leads to resistance to paclitaxel. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 10 | Her2 nuclear expression decreases paclitaxel-induced apoptosis. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 11 | CONCLUSION: We show for the first time that nuclear Her2 contributes to paclitaxel resistance in breast cancer cells which suggests that nuclear Her2 as a potential target to sensitize breast cancers to paclitaxel treatment. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 12 | CONCLUSION: We show for the first time that nuclear Her2 contributes to paclitaxel resistance in breast cancer cells which suggests that nuclear Her2 as a potential target to sensitize breast cancers to paclitaxel treatment. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 13 | CONCLUSION: We show for the first time that nuclear Her2 contributes to paclitaxel resistance in breast cancer cells which suggests that nuclear Her2 as a potential target to sensitize breast cancers to paclitaxel treatment. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 14 | CONCLUSION: We show for the first time that nuclear Her2 contributes to paclitaxel resistance in breast cancer cells which suggests that nuclear Her2 as a potential target to sensitize breast cancers to paclitaxel treatment. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |