Title : Proliferation of MDA-MB-231 can be suppressed by dimeric-epigallocatechin gallate through competitive inhibition of amphiregulin-epidermal growth factor receptor signaling.

Pub. Date : 2021 Jun 1

PMID : 33587351






7 Functional Relationships(s)
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1 Amphiregulin (AREG) is the most abundant epidermal growth factor receptor (EGFR) agonist in MDA-MB-231 TNBC cells, whose proliferation can be inhibited by (-)-epigallocatechin gallate (EGCG), a constituent of green tea that is prone to oxidative polymerization. epigallocatechin gallate epidermal growth factor receptor Homo sapiens
2 Amphiregulin (AREG) is the most abundant epidermal growth factor receptor (EGFR) agonist in MDA-MB-231 TNBC cells, whose proliferation can be inhibited by (-)-epigallocatechin gallate (EGCG), a constituent of green tea that is prone to oxidative polymerization. epigallocatechin gallate epidermal growth factor receptor Homo sapiens
3 Amphiregulin (AREG) is the most abundant epidermal growth factor receptor (EGFR) agonist in MDA-MB-231 TNBC cells, whose proliferation can be inhibited by (-)-epigallocatechin gallate (EGCG), a constituent of green tea that is prone to oxidative polymerization. epigallocatechin gallate epidermal growth factor receptor Homo sapiens
4 Amphiregulin (AREG) is the most abundant epidermal growth factor receptor (EGFR) agonist in MDA-MB-231 TNBC cells, whose proliferation can be inhibited by (-)-epigallocatechin gallate (EGCG), a constituent of green tea that is prone to oxidative polymerization. epigallocatechin gallate epidermal growth factor receptor Homo sapiens
5 Levels of EGFR and p44/42 MAPK phosphorylation in MDA-MB-231 cells were significantly reduced by treatment with 10 muM dimeric-EGCG (P < 0.01). epigallocatechin gallate epidermal growth factor receptor Homo sapiens
6 Surface plasmon resonance analysis demonstrated that 10 muM dimeric-EGCG bound directly to the extracellular domain of EGFR, competitively inhibiting the binding of AREG to EGFR. epigallocatechin gallate epidermal growth factor receptor Homo sapiens
7 Surface plasmon resonance analysis demonstrated that 10 muM dimeric-EGCG bound directly to the extracellular domain of EGFR, competitively inhibiting the binding of AREG to EGFR. epigallocatechin gallate epidermal growth factor receptor Homo sapiens