Title : Succinate Accumulation Links Mitochondrial MnSOD Depletion to Aberrant Nuclear DNA Methylation and Altered Cell Fate.

Pub. Date : 2020

PMID : 33585836






2 Functional Relationships(s)
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1 Since MnSOD has significant effects on SDH activity, and succinate is a key regulator of TET enzymes needed for proper differentiation, we hypothesized that SOD2 loss would lead to succinate accumulation, inhibition of TET activity, and impaired erythroid precursor differentiation. tetramethylenedisulfotetramine superoxide dismutase 2, mitochondrial Mus musculus
2 Since MnSOD has significant effects on SDH activity, and succinate is a key regulator of TET enzymes needed for proper differentiation, we hypothesized that SOD2 loss would lead to succinate accumulation, inhibition of TET activity, and impaired erythroid precursor differentiation. tetramethylenedisulfotetramine superoxide dismutase 2, mitochondrial Mus musculus