Title : AITC inhibits fibroblast-myofibroblast transition via TRPA1-independent MAPK and NRF2/HO-1 pathways and reverses corticosteroids insensitivity in human lung fibroblasts.

Pub. Date : 2021 Feb 12

PMID : 33579280






3 Functional Relationships(s)
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Compound Name
Protein Name
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1 AITC inhibits fibroblast-myofibroblast transition via TRPA1-independent MAPK and NRF2/HO-1 pathways and reverses corticosteroids insensitivity in human lung fibroblasts. allyl isothiocyanate heme oxygenase 1 Homo sapiens
2 AITC significantly increased phosphorylated- extracellular signal-regulated kinase (ERK) 1/2 and heme oxygenase (HO)-1 protein expressions (P < 0.05) in TGF-beta1-treated cells. allyl isothiocyanate heme oxygenase 1 Homo sapiens
3 CONCLUSION: We found that AITC exerts protective effect on TGF-beta1-induced alpha-SMA induction by activating ERK1/2 MAPK and NRF2/HO-1 pathways in lung fibroblasts. allyl isothiocyanate heme oxygenase 1 Homo sapiens