Pub. Date : 2021 Feb 12
PMID : 33579280
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AITC inhibits fibroblast-myofibroblast transition via TRPA1-independent MAPK and NRF2/HO-1 pathways and reverses corticosteroids insensitivity in human lung fibroblasts. | allyl isothiocyanate | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | Combined inhibition with ERK1/2 mitogen-activated protein kinase (MAPK) and nuclear factor erythroid 2-related factor (NRF2) almost completely reversed AITC-induced alpha-SMA suppression (P < 0.05). | allyl isothiocyanate | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | Combined inhibition with ERK1/2 mitogen-activated protein kinase (MAPK) and nuclear factor erythroid 2-related factor (NRF2) almost completely reversed AITC-induced alpha-SMA suppression (P < 0.05). | allyl isothiocyanate | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 4 | CONCLUSION: We found that AITC exerts protective effect on TGF-beta1-induced alpha-SMA induction by activating ERK1/2 MAPK and NRF2/HO-1 pathways in lung fibroblasts. | allyl isothiocyanate | NFE2 like bZIP transcription factor 2 | Homo sapiens |