Pub. Date : 2021 Feb 10
PMID : 33578797
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Notably, myristoylated alanine-rich C-kinase substrate (MARCKS) and Wntless homolog protein (WLS) were upregulated in oxaliplatin-resistant cells compared to sensitive cells, as confirmed by qRT-PCR and Western blot analysis. | Oxaliplatin | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 2 | Notably, myristoylated alanine-rich C-kinase substrate (MARCKS) and Wntless homolog protein (WLS) were upregulated in oxaliplatin-resistant cells compared to sensitive cells, as confirmed by qRT-PCR and Western blot analysis. | Oxaliplatin | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 3 | We further demonstrated the activation of AKT and beta-catenin signaling (downstream targets of MARCKS and WLS, respectively) in oxaliplatin-resistant PANC-1 cells. | Oxaliplatin | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 4 | Additionally, we show that the siRNA-mediated suppression of both MARCKS and WLS enhanced oxaliplatin sensitivity in oxaliplatin-resistant PANC-1 cells. | Oxaliplatin | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 5 | Additionally, we show that the siRNA-mediated suppression of both MARCKS and WLS enhanced oxaliplatin sensitivity in oxaliplatin-resistant PANC-1 cells. | Oxaliplatin | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 6 | Taken together, our results provide insights into multiple mechanisms of oxaliplatin resistance in pancreatic cancer cells and reveal that MARCKS and WLS might be involved in the oxaliplatin resistance. | Oxaliplatin | myristoylated alanine rich protein kinase C substrate | Homo sapiens |